Consistent with molecular findings from tumor-based studies, two markers in this panel were shown to correlate with overall survival (OS) in patients with diffuse midline glioma in this cohort — the presence of an H3F3A/HIST1H3B mutation was predictive of poor overall survival consistent with the specific entity of H3K27M-mutant diffuse midline glioma, where as an IDH1 mutation predicted better OS (Pan et al., 2019). The gene discussed is IDH1; the disease is diffuse midline glioma.