In recent years, lncRNAs analysis and functional assays for various types of cancer have provided increasing evidence supporting the critical role of lncRNAs in HCC tumor growth and progression, such as HOTAIR (Hu et al., 2018), MALAT1 (Tao et al., 2018) and TUG1 (Sun et al., 2018). The gene discussed is TUG1; the disease is hepatocellular carcinoma.