LINC00346 can regulate CDK1/CCNB1 to inhibit apoptosis, promote cell invasion and regulate cell cycle of HCC by targeting miR-199a-3p, while LINC00346-miR-199a-3p-CDK1/CCNB1 signal axis can regulate p53 signaling pathway. This evidence concerns the gene CDK1 and hepatocellular carcinoma.