The effects of the ceRNA axis of LINC00346-miR-199a-3p-CDK1/CCNB1 on cell invasion, apoptosis and cell cycle of HCC was demonstrated in this study, which further proved the role of LINC00346 as an oncogene in HCC, and the mechanism of HCC was further investigated. This evidence concerns the gene CCNB1 and hepatocellular carcinoma.