Indeed, in a bladder cancer rat model a 46% reduction in tumor burden in response to intravesical ALT-803 and BCG combination therapy (compared to 15% with BCG alone and 35% with ALT-803 alone) was linked to increased production and secretion of IL-1α, IL-1β, and RANTES, which in turn, induced the proliferation and activation of NK cells. This evidence concerns the gene GPT and urinary bladder carcinoma.