Indeed, MDSCs support the generation of a hostile tumor microenvironment by producing metabolites and soluble factors, as well as by expressing membrane-bound proteins which interfere with effector T cell function and fitness (58) or by promoting the generation of Foxp3 (forkhead box P3)-expressing immunosuppressive B regulatory (Breg) (59) and T regulatory (Treg) lymphocytes (60) as summarized in Figure 2. The gene discussed is FOXP3; the disease is neoplasm.