Moreover, both MDSCs and tumor cells secreted high-mobility group box-1 (HMGB1), a damage-associated molecular pattern protein whose signaling trough both Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE), activates EMT-inducing transcription factors (i.e., Snail and NF-κB) and up-regulates matrix metalloproteinase-7 (MMP7) (105). This evidence concerns the gene HMGB1 and neoplasm.