In melanoma bearing mice, in fact, PMN-MDSCs induce EMT by releasing TGF-β and hepatocyte growth factor (HGF) (103); moreover EMT was finely tuned by MDSC-secreted factors such as TGF-β release in combination with high amount of NO in nasopharyngeal carcinoma (104). This evidence concerns the gene TGFB1 and nasopharyngeal carcinoma.