Level of circulating inflammatory cytokines (TNF-α, IFN-γ, IL-6, IL-10, IL-12, IL-17A, IL17C &IL-22) pre and post intervention. [Time Frame: change from pre intervention baseline level at post 6 months intervention]. The level of eight colorectal cancer-related inflammatory cytokines (pg/mL) were measured and compared pre and post intervention in both the probiotic and placebo groups. This evidence concerns the gene IL10 and colorectal cancer.