In case of benign proliferative breast diseases and various type of breast cancers, the level of IGFBP2 both in serum and tumor mass may be upregulated (24, 25), moreover, IGFBP2 has proliferative effect on breast cancer cell lines (26) and it is associated with the endocrine resistance of breast cancer (27), which suggests that IGFBP2 is oncogenic and it is a potential biomarker (16). This evidence concerns the gene IGFBP2 and breast carcinoma.