Currently, a phase I clinical trial is going on with pUMVC3 vector and IGFBP2, HER2, and IGF1R to study the side effects and to determine the best dose of a vaccine therapy in preventing cancer recurrence in patients with non-metastatic, node positive, HER2 negative breast cancer (Clinicaltrials.gov ID: NCT02780401). This evidence concerns the gene IGFBP2 and breast carcinoma.