There are similar results in the literature: IGFBP2 inhibits the proliferation of human breast cancer cell line Hs578T (29), which does not express IGFBP2, similarly to 4T1 (data not shown), suggesting that the pro- or anti-tumorigenic effect of IGFBP2 depends on the actual state of the cancer cell. Here, IGFBP2 is linked to breast carcinoma.