Conversely, an analysis of anti-PD-1/PD-L1 agents plus chemotherapy in comparison to chemotherapy alone in lung cancer patients found that women had a large OS advantage with combined anti-PD-1/PD-L1 with chemotherapy vs. chemotherapy alone, with a much smaller benefit observed in the male patients (OS-HR = 0.44 vs. 0.76 for female vs. male, respectively) (50). This evidence concerns the gene CD274 and lung carcinoma.