Mechanism-related gene sets of MetS were selected from MSigDB and analyzed within our groups (10, 33), and the results showed that differences in the expression of genes, such as IGF1, IGFALS, CSF1, TGFβ1, and TGFβ2, were associated with MetS (Figure 2A, Supplementary Table 1). This evidence concerns the gene IGFALS and metabolic syndrome.