INS and diabetes mellitus: The American Diabetes Association (ADA) recommended starting treatment with insulin when the serum glucose level is persistently high, more than or equals to 180 mg/dL (10.0 mmol/L) [10]. With insulin therapy, the target blood glucose for the majority of in-patients should range from 140-180 mg/dL (7.8-10 mmol/L). In some groups of patients, a more strict glycemic goal, such as blood glucose ranges from 110-140 mg/dL, might be applicable [10].