Of various isoforms of SNARE proteins, SNAP-23, syntaxin-4, and VAMP-2 are highly expressed in skeletal muscle tissue and control GLUT4 trafficking in muscle cells (8, 9); consequently, dysfunction of this ternary complex and changes in SNARE proteins levels can cause T2DM (10). This evidence concerns the gene SLC2A4 and type 2 diabetes mellitus.