TP53 and Miyoshi myopathy: Silencing of MAGE-A family members in either p53 wt or null (mutated and/or deleted) human MM cell lines (HMCL) by RNA interference (RNAi) resulted in rapid induction of intrinsic apoptosis, characterized by mitochondrial membrane depolarization, upregulation of pro-apoptotic BAX and cleavage/activation of Caspases 3 and 9, and decreased proliferation characterized by loss of entry into S phase [9].