M2 macrophages, instead, are activated by anti-inflammatory cytokines (IL-4, IL-10) and the phosphatidiylinositol-3-kinase (PI3K) serine-threonine-kinase (Akt) and mammalian target of Rapamycin (TOR) pathway [23] and exert immunosuppressive effects, enhance angiogenesis and tumor progression. Here, AKT1 is linked to neoplasm.