M1 macrophages are activated by Interferon-Gamma (INF-γ) or Lipopolysaccharide (LPS) and exhibit anti-tumor properties through the production of pro-inflammatory cytokines (Interleukin 1 Beta, (IL-1β), Interleukin-6 (IL-6)) and inducible factors against pathogens such as the Tumor Necrosis Factor (TNFα) and the Nitric Oxide Synthase (INOs) [18–22]. This evidence concerns the gene TNF and neoplasm.