ABCB1 and leukemia: In a vinorelbine-resistant P388 mouse leukemia cell line model overexpressing high level of functional P-glycoproteins, F14512 displayed a strong antileukemic activity and the antitumor activity of F14512 was not impacted by the MDR status of cancer cells [Annereau JP, Brel V, Riquet W, Créancier L, Vandenberghe I, Fournier E, Robichon C, Stennevin A, Offrete V, Lacastaigneratte L, Gomes B, Kruczynski A, Bailly C, et al. Abstract 988: F14512, a novel vectorized topoiserase II inhibitor, bypasses MDR1 mediated resistance.