IL6 and systemic lupus erythematosus: Here, we linked reduced expression levels of let-7f in SLE BM-MSCs to their impaired immunoregulatory functions, including the proliferation rate of BM-MSCs, BM-MSC-mediated downregulation of Th17 cells and upregulation of Treg cells as well as increases the apoptosis rate of BM-MSCs through targeting IL-6 and activating STAT3 pathway.