RHOA and systemic sclerosis: We secondly explore possible mechanisms that could explain an impaired efferocytosis, with a specific focus on MΦ polarization and on the RhoA/ROCK pathway, a key regulator of cell adhesion, cytoskeleton remodeling and phagocytosis, that has been recently advanced as a promising therapeutic target in fibrotic disease and especially in SSc (23, 24).