Here, we explored the gene-editing technology using the CRISPR system to edit Keap1 gene in mesenchymal stem cells so as to increase the anti-oxidative ability of the stem cells, helping them survive, and we found that the CRISPR/Cas9 gene-editing technology might be a good way to treat traumatic brain injury by enhancing cell anti-oxidant ability through gene editing. The gene discussed is KEAP1; the disease is brain injury.