In addition to this data, it is known that wogonin has been demonstrated in separate instances to have inhibitory activity on SHH (Owen et al., 2017) and WNT signaling (Song et al., 2015), processes which are upregulated in osteoarthritis (Luyten et al., 2009; Chang et al., 2012) and mediated by the primary cilium. This evidence concerns the gene SHH and osteoarthritis.