Most of the myokines measured were regulated by acute exercise (FGF21, IL-6, IL-8, IL-15, and IL-18), and some were released at different levels in plasma over the 24 h in the group of women with obesity in comparison to the non-obese group (SPARC, IL-8, and IL-13). The gene discussed is FGF21; the disease is obesity due to melanocortin 4 receptor deficiency.