Reverted mitochondrial dysfunction induced by HFD and hyperglycemia in skeletal muscle, in part due to an ↑ in mitochondrial biogenesis. The prevention of mitochondrial dysfunction, ↑ in mitochondrial biogenesis, and BBR-induced AMPK activation, are blocked in cells in which SIRT1 has been knocked down. The gene discussed is SIRT1; the disease is Hyperglycemia.