Although nothing is known regarding the state of CMA in ALS or FTLD patients, where TDP-43 aggregation is implicated, some reports have shown that Lamp2A and Hsc70 protein levels are altered in other neurodegenerative diseases (Papagiannakis et al., 2015; Klaver et al., 2018; Loeffler et al., 2018). This evidence concerns the gene HSPA8 and amyotrophic lateral sclerosis.