Further evidence of change in glycolysis was found in the decrease of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) in HCC cells (data not shown), which is an allosteric activator of 6-phosphofructokinase-1 (PFK-1), a glycolysis stimulator. Here, PFKM is linked to hepatocellular carcinoma.