Patients with higher PCT levels13, 14 or those in whom the PCT levels remain elevated for longer duration despite treatment tend to have a worse prognosis compared to the ones with lower levels of PCT or in whom the PCT level decreases soon after initiation of antibiotics.15-18 While PCT use as a diagnostic tool for sepsis or to decide to initiate antibiotics has been controversial, the evidence supporting PCT use in the discontinuation of antibiotics is stronger. Here, CALCA is linked to Sepsis.