MAPT and early-onset autosomal dominant Alzheimer disease: Gao-Shang Chai et al. (2014) 13 have found that HN attenuates: the Amyloid β-peptide induced memory deficits, tau phosphorylation, dendritic degeneration, neuronal apoptosis and neuronal dysfunction; then could ameliorate the senile dementia present in individuals with Alzheimer's disease 13.