NK cells also undergo dramatic metabolic reprogramming, a process that is strictly regulated by mTORC1 activity.94 Not only is mTORC1 required in order to maintain and attain an highly glycolytic metabolic state, mTORC1 activity is also essential for production of key NK cell effector molecules including IFNγ and granzyme B. The role of NK cells in autoimmune disease as evaluated in various animal models has proven somewhat contradictory with both disease-controlling and disease-promoting outcomes. Here, IFNG is linked to autoimmune disease.