SLC2A1 and psoriasis: Interestingly Zhang et al. recently demonstrated using Glut1 deficient keratinocytes, that high reliance on Glut1 and glucose metabolism is uniquely required for proliferating keratinocytes in vivo as would occur in psoriasis.129 Whilst Glut1−/− primary epidermal keratinocytes displayed impaired proliferation in vitro, surprisingly skin development in these mice in vivo was normal, suggesting Glut1 may be dispensable for normal epidermal development and differentiation.