PKM and serum lipopolysaccharide activity: This occurs endogenously when the metabolites fructose-1,6-bisphosphate, as well as serine and succinylaminoimidazolecarboxamide ribose 5’-phosphate (SAICAR) bind to PKM2.151 PKM2 can also be activated using highly specific small-molecule activators such as TEPP-46.152 TEPP-46 inhibits inflammatory markers in LPS-induced endotoxemia.