PKM2 of renal proximal tubules is regulated by the S-nitroso-CoA (SNO)/S-nitroso-CoA reductase (SCoR) system whereby oxidative modification of Cys on PKM2 forms S-nitrosothiol (SNO) and provides a means of sensing eNOS activity and protecting against renal kidney injury. Here, PKM is linked to urogenital neoplasm.