IFNG and autoimmune disease: Inhibition of mTOR with Rapamycin promotes tolerance, such that T cells stimulated in the presence of Rapamycin fail to produce IL-2 or IFNγ upon re-challenge, making inhibition of mTOR an attractive approach for preventing transplant rejection.91,92 Paradoxically, although administration of high doses of rapamycin attenuates autoimmune disease and can be used to treat transplant rejection, low dose rapamycin appears to enhance memory T cell population and function in inflammatory eye disease.93