CD8A and myeloid sarcoma: Furthermore, DMF modulates lipid metabolism and fatty acid levels in MS patients, changes that correlate with changes in immunological parameters such as absolute lymphocyte counts and CD8+ T cell subsets.35 Nrf2 drives mitochondrial fatty acid oxidation,36 whilst suppressing both lipid biosynthesis and expression of key desaturation genes including fatty acid synthase (FAS) and stearoyl-CoA desaturase 1.37