We also queried the mutational profile of TCGA-COAD and found that in high-miR-27a CRC samples there was a significant higher frequency of mutations of canonical cancer drivers in CRC, i.e. APC and K-RAS (p < 0.05; likelihood ratio test) (Fig. 1e, Supplementary Fig. 1E). The gene discussed is KRAS; the disease is colorectal carcinoma.