TSC1 and neoplasm: Notably, AMPK modulates TSC1/2 and the downstream factor RHEB, a repressor of mTOR complex 1.38,39 Therefore, we hypothesised that miR-27a overexpression by downmodulating AMPK would activate the mTOR pathway and the associated protein synthesis, ultimately sustaining tumour biomass production in the context of aerobic glycolysis.