MTOR and colorectal carcinoma: Having shown that miR-27a modulates pathways involved in mitochondrial dysfunction, oxidative phosphorylation and mTOR signalling network as from our in silico analysis (Fig. 1b), we investigated the impact of miR-27a expression variations on metabolism in a panel of CRC cell lines previously assessed for miR-27a levels.26 To this goal, the high-miR-27a expressing HCT116 and SW480 cells (Supplementary Fig. 2A) were transduced with viral vectors carrying a short hairpin anti-sense RNA to generate pools of clones, henceforward named miR-27a_KD cells.