TLR5 and systemic lupus erythematosus: Treatment of normal or B6.Sle1.Sle2.Sle3 lupus-prone mice using the hexokinase inhibitor, 2-deoxy-d-glucose (2DG), had no effect on the induction of antigen-induced GC B cells and corresponding antibodies, but it greatly reduced the induction of autoreactive GC B cells in lupus-prone mice8.