In mammals, BACH1 is expressed ubiquitously and has been shown to act either as an activator or repressor of transcription and to be involved in oxidative stress, metabolism, cell transformation, neurodegenerative diseases, tumor expansion, and metastatic spread (Watari et al, 2008;, Warnatz et al, 2011;, Nakanome et al, 2013;, Igarashi & Watanabe-Matsui, 2014;, Lee et al, 2014;, Zhou et al, 2016;, Lee et al, 2019;, Lignitto et al, 2019;, Wiel et al, 2019). Here, BACH1 is linked to neurodegenerative disease.