CXCR4 and Familial prostate cancer: Furthermore, ablation of BACH1 in human colon carcinoma (Davudian et al, 2016b) or in prostate cancer cells (Shajari et al, 2018) prevents cell growth, migration, and invasion in vitro, decreasing the expression of its main metastasis-related genes, MMP1, let-7a, and CXCR4.