For example, adverse events reported in the FDA Adverse Event Reporting System document IgE-mediated anaphylactic/anaphylactoid reactions triggered by CHG exposure and, although they are very rare, they are increasingly reported in association with surgical procedures.30 Hypersensitivity reactions mediated by other mechanisms have also been recognized.31 It has been suggested that the number of patients who will present with an acute allergy to CHG is likely to increase over time.31,32. Here, IGHE is linked to allergic disease.