The increased concentration of VDAC1 in hyperphoshorylated tau-expressing CA1 neurons in 12-mo Tg mice, but not in 6-mo Tg mice, is in line with a previous report showing high expression of VDAC1 in AD brains at advanced stages of the disease and in AD transgenic mouse brain [18]. Here, VDAC1 is linked to Alzheimer disease.