COL24A1 and Ehlers-Danlos syndrome: An important paralog of COL24A1 is COL5A1. Mutations in the COL5A1 gene, encoding the alpha 1 of type V collagen, have been identified in patients with Ehlers-Danlos syndrome [50, 51] which has been linked to hallux valgus [52], Achilles tendinopathy [50], acquired injuries such as ACL tears [53], and with range of motion [50].