However, the fully-adjusted HOMA-IR model (Model 2) estimated no significant association between higher leptin levels and incident type 2 diabetes (HR = 0.99; 95% CI = 0.80, 1.22; P = 0.92) but did show significance with adiponectin (HR = 0.73; 95% CI = 0.61, 0.86; P = 0.0003) (Table 2). This evidence concerns the gene LEP and type 2 diabetes mellitus.