BRAF and melanoma: BRAF V600E mutation causes aberrant MAPK signaling and drives 40–50% of melanomas [1, 2], 10% of colorectal cancers [3, 4],1–2% of lung adenocarcinomas [5, 6], 50% of the well differentiated thyroid carcinomas [7] and the vast majority of hairy cell leukemia cases [8] following the oncogene addiction disease model.