RNLS and chronic kidney disease: Most of results show, that concentration of renalase in serum of subjects with CKD, hemodialyzed, renal transplant recipients or patients with coronary artery disease (CAD) is higher when compared to healthy subjects [1, 10–12], while one Western blot study performed on human blood plasma showed a decrease in concentration of this protein in end-stage renal disease (ESRD) [1].