In our cohort of participants who had been on ART for a median of one year, we found that the immune activation in HIV+TB, measured as a proportion of CD38+HLA-DR+totalcytokine+ ESAT-6/CFP-10-responding CD4+ T-cells, was comparable to HIV−TB but higher than LTBI at the time of TB diagnosis. The gene discussed is CD4; the disease is tuberculosis.