Representative dot plots of the cytokine response to the four stimulation conditions are shown in the top panel of Figure 2A. At the time of TB diagnosis, IL-2−IFN-γ+TNFα+CD4+ T-cell responses to ESAT-6/CFP-10 stimulation were significantly higher in TB compared to LTBI but did not differ by HIV status (Figure 2B). The gene discussed is TNF; the disease is tuberculosis.