Considering the importance of synovium-induced angiogenesis in OA pathogenesis, we sought to elucidate existing crosstalk between APLN and VEGF in human osteoarthritis synovial fibroblasts (OASFs) and OA animal models (anterior cruciate transection; ACLT) in order to clarify the association between obesity, adipokine, adipokine-induced angiogenesis and OA. Here, VEGFA is linked to osteoarthritis.