However, the question arises when we try to ascertain natural PrPC functions and their specific roles in NDDs other than prionopathies because not only PrPSc (see above) but also PrPC can coexist with most of these amyloids in experimental NDD models and in brain affected tissue (i.e., [22,47,48,49,50]). Here, PRNP is linked to Neurodevelopmental delay.