Moreover, oxidative stress is an important contributing factor in the pathogenesis of many human NDDs, such as prionopathies, Parkinson’s, Huntington’s, Alzheimer’s, and amyotrophic lateral sclerosis [152,153,154], which leads us to pose the question of what the role of PrPC is in each of these scenarios. The gene discussed is PRNP; the disease is Parkinson disease.