We believe that this novel scaffold of 1-pyrimidinyl-2-aryl-4,6-dihydropyrrolo[3,4-d]imidazole-5(1H)-carboxamide derivatives will be highly useful in the development of JNK3-selective inhibitors as therapeutic agents for neurodegenerative diseases. The gene discussed is MAPK10; the disease is neurodegenerative disease.