Among these, the single nucleotide polymorphism in residue 148 (I148M, rs738409) in human patatin-like phospholipase domain containing 3 (PNPLA3) gene, encoding the protein adiponutrin, has been recognized as one of the strongest genetic factors leading to NAFLD development [39,40]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.