TCF4 and gastrointestinal disease: lushanensis and used to prevent gastrointestinal diseases, inhibited proliferation of human colorectal cancer cells HCT116, downregulating the Wnt cascade by impairing association of the β-catenin/TCF4 transcriptional complex, likely through directly blocking the binding of β-catenin to TCF4, while cytoplasmic and nuclear levels of β-catenin are not affected [148].