Ethanol extracts of the Scutellaria barbata plant reduced colorectal cancer cell (HT-29) xenograft growth in mice, and downregulation of Wnt signaling in the tumors was verified at the protein level of expression of Wnt target genes c-myc, survivin and APC, and β-catenin itself as well as β-catenin phosphorylation levels [162]. The gene discussed is APC; the disease is colorectal cancer.