Among other mechanisms, such as increased IAPP secretion during prediabetes [12] or insufficient processing of IAPP as found in failing human islet grafts [13], IAPP is also one of the strongest activators of the NLRP3 inflammasome [14], which leads to activation and secretion of mature Interleukin 1β (IL-1β). Here, IAPP is linked to prediabetes syndrome.