Nudt7−/− mice developed more polyps (Figure 4A) and adenocarcinoma (Figure S5) and showed the dramatically increased Ki67- (expressed in colonic glands and proliferating cells; 1.32 fold of Nudt7−/−_AOM/DSS colon), F4/80- (expressed in immune cells; 2.79 fold of Nudt7−/−_AOM/DSS colon), LY6G- (expressed immune cells; 2.47 fold of Nudt7−/−_AOM/DSS colon), and SCD1- (3.70 fold of Nudt7−/−_AOM/DSS colon) positive cells in colons (Figure 4B,C). The gene discussed is NUDT7; the disease is infectious otitis media.