Exome sequencing of common familial CRC suggested 11 novel candidate CRC susceptibility genes, including Uaca, Sfxn4, Twsg1, Psph, Nudt7, Znf490, Prss37, Ccdc18, Pradc1, Mrpl3, and Akr1c4, with rare truncating variants [3]. The gene discussed is PSPH; the disease is colorectal carcinoma.