In human CRC tumors, the expression levels of Nos2, Sod2, Acot2, Xdh, Acot1, Crat, Crot, Phyh, Sod1, and Hao1 were significantly increased (p ≤ 0.05), whereas the expression levels of Nudt7, Acsl5, Abcd3, Acsl3, Far1, Pex12, Rhoc, Acsl4, Ehhadh, Ech1, Dnajc10, Acaa1, Agps, Acsf3, Trim37, Pex6, and Hmgcl were significantly decreased (p ≤ 0.05) in KrasG12D CRC tumors (Figure S1B,C; including functional categories for these genes according to peroxisome database). This evidence concerns the gene ACOT1 and colorectal carcinoma.