KDR and neoplasm: We analyzed the following molecular markers by QPCR: RPIA, cyclin D1 (ccnd1), wnk1a and wnk1b, flk1, and matrix metalloproteinase 9, and mmp9. The ccnd1 is required for cell cycle and cell proliferation in CRC, while mmp9 is involved in the breakdown of extracellular matrix, which is important for tumor neovascularization and metastasis.