To support the notion that WNK1 indeed stimulates angiogenesis to contribute to tumor growth, we generated transgenic fish Tg (fli1:wnk1a; my17:EGFP) that drives wnk1a expression in endothelium via fli1 promoter and crossed with Tg (fabp10a:HBx-mCherry, src; my17:EGFP; p53-) transgenic fish which carries mutations in p53 tumor suppressor, such that hepatoma develops with an accelerated rate [26]. This evidence concerns the gene TP53 and hepatocellular carcinoma.