NOTCH1 and neoplasm: In parallel, SOX2 was found to cooperate with important oncogenes, like Wnt1 (OMIM: 164820), Wnt2 (OMIM: 147870), c‐Myc (OMIM: 190080), and Notch1 (OMIM: 190198), to promote lung tumor occurrence, while downregulation of SOX2 inhibited proliferation and induced apoptosis in tumor cells (Chen et al., 2012).