We discovered that miR‐143‐3p suppressed OSCC progression via targeting MYO6. The data revealed that MYO6 exhibited a tumor‐promoting property in various cancers, including prostate,19 gastric,21 breast,49 and lung cancer.50 Moreover, consistent with previous studies, we observed that MYO6 is a downstream target for miR‐143‐3p,51 and that MYO6 can also be regulated by lncRNA such as SOX21‐AS1. This evidence concerns the gene SOX21 and lung cancer.