LncRNA UCA1 is elevated in the bile duct carcinoma (BDC) and promotes BDC cell migration and invasiveness.7 Moreover, lncRNA UCA1 can promote human pancreatic ductal adenocarcinoma stem cell properties and suppress tumor growth.8 The oncogenic role of lncRNA UCA1 in other cancers, including glioblastoma,9 bladder,10 gastric,11 and prostate cancer,12 has been reported, the function of UCA1 in OSCC remains to be elucidated. This evidence concerns the gene UCA1 and cancer.