Studies suggest that UCA1 serves as an oncogene in various human cancers, for instance, it promotes the growth of adrenocortical cancer cells, while silencing UCA1 can inhibit hemangioma cell growth, migration, and invasion.30, 31UCA1 also plays an oncogenic role in nasopharyngeal carcinoma,32 osteosarcoma,33 colon,34 and pancreatic cancer.35 Additionally, UCA1 can act as a potential molecular marker for metastasis and prognosis in multiple cancers.36 In our study, UCA1 increased both in OSCC tissues and cells and promoted OSCC progression in vitro and in vivo. The gene discussed is UCA1; the disease is cancer.