Dysregulation of lncRNAs, including HOXA11‐AS, LEF1‐AS1, and TUG1, is involved in OSCC progression.26, 27, 28 Moreover, lncRNA ADAMTS9‐AS2 can promote tongue squamous cell carcinoma proliferation, migration, and EMT.29 However, the roles of lncRNAs in OSCC progression have not been clearly elucidated. This evidence concerns the gene LEF1 and tongue squamous cell carcinoma.