Previous studies showed that EMT plays a pivotal role in tissue metastasis.37 LncRNAs are involved in EMT, for instance, the knockdown of lncRNA SNHG7 suppresses EMT in prostate cancer,38 and downregulated HAGLR inhibits EMT and metastatic potential in esophageal cancer.39 As a result, UCA1 may be conducive to OSCC metastasis via facilitating the EMT process. This evidence concerns the gene HAGLR and esophageal cancer.