Myosin VI (MYO6), which is widely expressed in various organisms and tissues, is a unique member of the myosin superfamily.18MYO6 could serve as an oncogene in human cancers, for instance, knocking down MYO6 suppresses the growth and induces the apoptosis in prostate cancer, colorectal cancer, and gastric cancer.19, 20, 21 In addition, knockdown of MYO6 also inhibits the proliferation of OSCC cells.22 Although MYO6 has been reported in many human tumors, including OSCC cells, its role in OSCC is unknown. The gene discussed is MYO6; the disease is prostate cancer.