TIMM50 and esophageal squamous cell carcinoma: Cytoplasmic lncRNAs have been reported to participate in regulating protein stability via ubiquitination.40, 41 For example, an oncogenic lncRNA GLCC1 was proven to stabilize transcriptional factor c‐Myc from ubiquitination degradation through directly binding to HSP90 chaperon.51 Moreover, we found that Tim50 overexpression partially abolished the reduction of ESCC cell proliferation caused by LOC100133669 knockdown.