lncRNA DANCR was evidenced to be a direct MYC target that suppresses p21 expression to promote cell proliferation.47 lncRNA BLACAT1 was found to play a role in G0/G1 arrest by interacting with EZH2 to inhibit p15 expression.48 In our study, LOC100133669 was shown to accelerate the cell cycle procession of ESCC cells both from G2/M phase to G0/G1 phase and from G0/G1 phase to S phase. The gene discussed is MYC; the disease is esophageal squamous cell carcinoma.