For this, Faul et al. administered recombinant FGF23 (rFGF23) to isolated cardiomyocytes and to wild type and klotho deficient mice, where subsequently hypertrophic growth of the myocytes and cardiac hypertrophy in mice was observed, even so in the klotho knock-out animals [18]. The gene discussed is KL; the disease is cardiac hypertrophy.