CKD is defined as an estimated glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m2 or the presence of increased urinary albumin excretion (microalbuminuria), indicated by urine albumin-to-creatinine ratio [uACR] of 3.0–30.0 mg/mmol), or overt proteinuria (uACR > 30.0 mg/mmol), all of which are independent risk factors for CV and kidney disorders in the general population and in patients with diabetes [9]. This evidence concerns the gene ALB and diabetes mellitus.