The mTORC1 complex is a nutrient sensor that, through activation of c-myc, drives cancer progression and metabolic reprogramming, characterized by upregulation of glycolysis, despite the presence of sufficient oxygen, and simultaneously limiting OxPhos, a phenomenon known as the Warburg effect (Harachi et al. 2018; Vander Heiden et al. 2009; Warburg 1956). The gene discussed is MYC; the disease is cancer.