Reports about WISP1 mainly concentrated on WISP1/β-catenin signaling pathway[30], like our previous study about WISP1 interacting with β6 [19, 31] or with β3 [32, 33], which was related to alveolar–capillary permeability in VILI or ALI/ARDS. The gene discussed is CCN4; the disease is acute respiratory distress syndrome.