MINDY4 and Machado-Joseph disease: The human genome codifies approximately 90 DUBs that are classified into six families: ubiquitin C-terminal hydrolases (UCHs), ubiquitin-specific proteases (USPs), Machado-Joseph Disease (MJD), Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes (PPPDE), ovarian tumor (OTU), metalloproteases with a JAMM/MPN motif, and the recently described motif interacting with Ub-containing protein (MINDY-4).4